Evaluation of Antidiabetic Activity of Bauhinia purpurea Linn in Streptozotocin Induced Diabetic Rats

The present study was expected to evaluate anti diabetic activity ofethanol extracts of Bauhinia purpurea Linn plant parts Viz stem, root. Leaf and flowers in Wister rats.Diabetes mellitus was induced in rats by single intraperitoneal injection ofstreptozotocin (STZ, 50 mg/kg body weight). After STZ induction, the hyperglycemicrats were treated with all three extracts orally at the dose 200 mg/kg body weight dailyfor 15 days. Glibenclamide (0.5 mg/kg b. w., p.o.) was used as reference drug. Thefasting blood glucose levels were measured on every 5th day during the 15 daytreatment. All the extracts at 100, 200,400 mg/kg orally significantly (p < 0.001) exhibited antidiabetic activity in STZ-induced diabetic rats by reducing and normalizing the elevatedfasting blood glucose levels as compared to those of STZ control group. The methanolextract was most active. The present study concludes that Bauhinia purpura Linn confirmed promising anti diabetic activity in STZ-induced diabetic Wister rats.